Search results for "Binge alcohol drinking"

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Binge-like alcohol exposure in adolescence: behavioural, neuroendocrine and molecular evidence of abnormal neuroplasticity … and return

2021

Binge alcohol consumption among adolescents affects the developing neural networks underpinning reward and stress processing in the nucleus accumbens (NAc). This study explores in rats the long-lasting effects of early intermittent exposure to intoxicating alcohol levels at adolescence, on: (1) the response to natural positive stimuli and inescapable stress

Binge alcohol drinkingmedicine.medical_specialtySettore BIO/14 - FARMACOLOGIAQH301-705.5Medicine (miscellaneous)Nucleus accumbensArticleGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineDopamineDopamine receptor D2Internal medicineNeuroplasticityMedicineCannabidiol[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Biology (General)030304 developmental biologyDopamine transporter0303 health sciencesbiologyTyrosine hydroxylasebusiness.industryDopaminergicAdolescenceEndocrinologybiology.proteinNucleus accumbens[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Adolescence Binge alcohol drinking Cannabidiol Nucleus accumbensbusinessCannabidiol030217 neurology & neurosurgerymedicine.drug
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Social stress under binge-like alcohol withdrawal in adolescence: evidence of cannabidiol effect on maladaptive plasticity in rats.

2022

Abstract Background Alcohol binge drinking may compromise the functioning of the nucleus accumbens (NAc), i.e. the neural hub for processing reward and aversive responses. Methods As socially stressful events pose particular challenges at developmental stages, this research applied the resident–intruder paradigm as a model of social stress, to highlight behavioural neuroendocrine and molecular maladaptive plasticity in rats at withdrawal from binge-like alcohol exposure in adolescence. In search of a rescue agent, cannabidiol (CBD) was selected due to its favourable effects on alcohol- and stress-related harms. Results Binge-like alcohol exposed intruder rats displayed a compromised defensi…

cannabidiolPsychiatry and Mental healthnucleus accumbensocial stressbinge alcohol drinkingSettore BIO/14 - FarmacologiaApplied PsychologyAdolescencePsychological medicine
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Environmental Enrichment During Adolescence Mitigates Cognitive Deficits and Alcohol Vulnerability due to Continuous and Intermittent Perinatal Alcoh…

2020

Perinatal alcohol exposure affects ontogenic neurodevelopment, causing physical and functional long-term abnormalities with limited treatment options. This study investigated long-term consequences of continuous and intermittent maternal alcohol drinking on behavioral readouts of cognitive function and alcohol vulnerability in the offspring. The effects of environmental enrichment (EE) during adolescence were also evaluated. Female rats underwent continuous alcohol drinking (CAD)—or intermittent alcohol drinking paradigm (IAD), along pregestation, gestation, and lactation periods—equivalent to the whole gestational period in humans. Male offspring were reared in standard conditions or EE un…

perinatal binge alcohol drinkingOffspringCognitive NeurosciencePhysiologyMorris water navigation taskAlcohollcsh:RC321-57103 medical and health scienceschemistry.chemical_compoundBehavioral Neuroscience0302 clinical medicineLactationMedicinelcsh:Neurosciences. Biological psychiatry. Neuropsychiatry030304 developmental biologyOriginal Researchspatial memory.0303 health sciencesEnvironmental enrichmentbusiness.industryalcoholCognitive flexibilityCognitionalcohol vulnerabilityspatial memoryNeuropsychology and Physiological Psychologymedicine.anatomical_structurechemistrydeclarative memorySettore BIO/14 - Farmacologiaenvironmental enrichmentGestationperinatal continuous alcohol drinkingbusiness030217 neurology & neurosurgeryFrontiers in behavioral neuroscience
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